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However, tumor resistance resulting from clinical used aromataseinhibitors and antiestrogens is unpredictable.
2
Then a newer class of drugs, the aromataseinhibitors, was developed.
3
Now, a new class of agents called aromataseinhibitors have emerged as an alternative.
4
Letrozole is one of aromataseinhibitors frequently used in treatment of men with oligospermia.
5
These concepts provide a strong rationale for studies of aromataseinhibitors to prevent breast cancer.
Использование термина aromatase inhibitor на английском
1
Ovarian suppression may be administered with either tamoxifen or an aromataseinhibitor.
2
We postulated that an aromataseinhibitor would be safer and more effective.
3
The clinical usefulness of this new aromataseinhibitor remains to be studied further.
4
Multivariable logistic regression analysis examined temporal associations and characteristics associated with aromataseinhibitor use.
5
Despite providing substantial improvements in patient outcome, aromataseinhibitor resistance remains a major clinical challenge.
6
Additional studies were performed in WT mice treated with the aromataseinhibitor fadrozole or vehicle.
7
We found a potent aromataseinhibitor through the screening of agents for estrogen-dependent breast cancer.
8
These include androgen-deprivation therapy for prostate cancer and aromataseinhibitor therapy for breast cancer, among others.
9
Furthermore, GDNF-RET signaling promoted the survival of aromataseinhibitor-resistant cells and elicited resistance in aromataseinhibitor-sensitive cells.
10
Recent findings: Oestrogen-deprivation therapy in the form of the aromataseinhibitor letrozole has demonstrated activity in three clinical studies.
11
No correlation was observed between aromatase or COX-2 expression and the response of the patients to aromataseinhibitor treatment.
12
During therapy with the Gn-RH analogue, patients who had a positive ER status after chemotherapy received an aromataseinhibitor.
13
If they are newly diagnosed we are using an aromataseinhibitor instead of tamoxifen, she said in a statement.
14
We validated these findings by showing increased RET protein expression levels in an independent cohort of aromataseinhibitor-resistant patient specimens.
15
The metabolism of the steroidal aromataseinhibitor atamestane was studied in the rat, the cynomolgus monkey and in the human.
16
In breast cancer cells in two-dimensional and three-dimensional culture, GDNF-mediated RET signaling is enhanced in a model of aromataseinhibitor resistance.